Hermányi I, Tamás G
Semmelweis Orvostudományi Egyetem II. Belgyógyászati Klinika, Budapest, Hungary.
Acta Diabetol Lat. 1988 Jan-Mar;25(1):33-40. doi: 10.1007/BF02581243.
The insulin treatment of 8 insulin-dependent diabetics was controlled with a microprocessor (Better Control Medical Computer, BCMC, Inc., Toronto, Canada) with information derived from blood or first voided urine glucose concentrations assessed by reagent strips four times a day, before the three main meals and bedtime snack. The microprocessor recommends modification of the insulin doses so as to reach a pre-prandial blood glucose value of 110 mg/dl or a urine glucose concentration of 0.1 g/dl. During the first two weeks self-management was uniformly applied by the patients, based on their blood glucose concentration. Subsequently, it was continued by the patients who were divided into two groups, one using the blood, the other the urine glucose concentrations, each for three weeks, alternately. During microprocessor treatment the patients' mean blood glucose profiles decreased from 152 +/- 37 mg/dl to 126 +/- 28 mg/dl. No difference was found between treatments based on blood or urine glucose concentrations concerning either the mean blood glucose profiles or the number of hypoglycemic episodes in the presence of an average glucose threshold and good renal function. The first voided urine glucose concentration and mean and maximal blood glucose values obtained at the time of urine filtration were closely correlated (r = 0.82 and 0.86, p less than 0.001).
对8名胰岛素依赖型糖尿病患者的胰岛素治疗，采用微处理器（加拿大安大略省多伦多市的Better Control Medical Computer公司生产的BCMC）进行控制，该微处理器依据每天三餐主餐和睡前小吃前用试纸条测定的血或首次晨尿葡萄糖浓度所获取的信息来进行操作。微处理器会建议调整胰岛素剂量，以使餐前血糖值达到110毫克/分升或尿葡萄糖浓度达到0.1克/分升。在最初两周，患者根据自身血糖浓度统一进行自我管理。随后，患者被分为两组继续进行，一组依据血糖浓度，另一组依据尿葡萄糖浓度，每组各持续三周，交替进行。在微处理器治疗期间，患者的平均血糖水平从152±37毫克/分升降至126±28毫克/分升。在平均葡萄糖阈值和肾功能良好的情况下，基于血糖或尿葡萄糖浓度的治疗在平均血糖水平或低血糖发作次数方面均未发现差异。首次晨尿葡萄糖浓度与尿液过滤时获得的平均血糖值和最大血糖值密切相关（r = 0.82和0.86，p＜0.001）。
