Hayford J T, Weydert J A, Thompson R G
Diabetes Care. 1983 Jan-Feb;6(1):40-44. doi: 10.2337/diacare.6.1.40.
Both physicians and diabetic patients have traditionally relied on measurement of glycosuria as an indirect method of estimating plasma glucose concentration to guide adjustment of insulin and diet therapy. Our observations on the correlation between mean plasma glucose concentration with simultaneous urine glucose concentration or excretion rate re-emphasize the limitations of this approach. Although our observations show a significant correlation (P less than 0.0001) between plasma glucose concentration and urine glucose concentration or urine glucose excretion rate, the wide confidence limits [95% confidence limits (minimum) +/- 150 mg/dl] on plasma glucose concentration estimated from urine glucose measurements limit the clinical applicability of such estimates. Differences among subjects in the renal resorption of glucose contribute to the wide variance of estimates. However, significant variability in renal glucose resorption within individuals is documented, further reinforcing the limitations of urine glucose determinations for reliable estimates of plasma glucose concentrations. Diabetologists need to reconsider the applicability of urine glucose measurements in evaluation of adequacy of therapy and in adjustment of insulin dosage.
传统上，医生和糖尿病患者都依赖于检测糖尿，将其作为估计血浆葡萄糖浓度的一种间接方法，以指导胰岛素和饮食治疗的调整。我们对平均血浆葡萄糖浓度与同时测定的尿葡萄糖浓度或排泄率之间相关性的观察结果再次强调了这种方法的局限性。尽管我们的观察结果显示血浆葡萄糖浓度与尿葡萄糖浓度或尿葡萄糖排泄率之间存在显著相关性（P小于0.0001），但根据尿葡萄糖测量值估算的血浆葡萄糖浓度的宽泛置信区间[95%置信区间（最小值）±150mg/dl]限制了此类估算在临床上的适用性。个体之间肾脏对葡萄糖重吸收的差异导致了估算值的广泛差异。然而，有记录表明个体内部肾脏葡萄糖重吸收存在显著变异性，这进一步强化了尿葡萄糖测定在可靠估算血浆葡萄糖浓度方面的局限性。糖尿病专家需要重新考虑尿葡萄糖测量在评估治疗充分性和调整胰岛素剂量方面的适用性。
