Alberico S, Mazza S, Grimaldi E, Volpe C, Guaschino S
Institute of Gynecology and Obstetrics, Burlo Garofolo Institute for Children, University of Trieste, Italy.
Clin Exp Obstet Gynecol. 1998;25(4):129-31.
Cryoglobulins are a group of proteins with the common property of precipitating from cooled serum. Cooled cryoglobulinemia is a classic disease caused by immune complexes which subside on vessel walls and produce a clinical picture represented by recurrent purpura, asthenia, arthralgias, Raynaud's phenomenon, glomerulonephritis and sensorimotor neuropathy. The authors describe a case of a patient C.M., 37 years old, with cryoglobulinemia, chronic hepatitis C and gravidic cholestasis at 28 weeks' gestation. The clinical picture worsened with the appearance of mild hypertension with proteinuria and hypochromic anaemia. At 31 weeks' the arthralgic symptomatology and pruritus revealed degeneration with an alteration of glycemic profile values and treatment with rapid human insuline was started. The cardiotocography began to be pathologic and a cesarean section was performed; the newborn weighted 1570 g. Cooled cryoglobulinemia is a pathology which worsens in a gravidic state and can impair the outcome of pregnancy.
冷球蛋白是一类具有从冷却血清中沉淀这一共同特性的蛋白质。冷球蛋白血症是一种由免疫复合物引起的经典疾病，这些免疫复合物沉积在血管壁上，产生以反复紫癜、乏力、关节痛、雷诺现象、肾小球肾炎和感觉运动性神经病变为表现的临床症状。作者描述了一例37岁的C.M.患者，患有冷球蛋白血症、慢性丙型肝炎且在妊娠28周时出现妊娠期胆汁淤积症。随着轻度高血压伴蛋白尿和低色素性贫血的出现，临床症状恶化。在妊娠31周时，关节痛症状和瘙痒加重，血糖谱值出现改变，开始使用速效人胰岛素进行治疗。胎心监护开始出现异常，遂行剖宫产；新生儿体重1570克。冷球蛋白血症是一种在妊娠状态下会恶化且可能影响妊娠结局的疾病。
