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[人及大鼠中肉孢子虫抗体的胎盘传递(作者译)]

[Diaplacental passage of Sarcocystis antibodies in man and rats (author's transl)].

作者信息

Aryeetey M E, Piekarski G

出版信息

Z Parasitenkd. 1978 Aug 7;56(3):211-8. doi: 10.1007/BF00931714.

Abstract

Sera of babies up to the age of 3 months were tested for Sarcocystis antibodies using the indirect immunofluorescence test (IIFT). In addition titre of the Sarcocystis antibody level of litters born to serologic Sarcocystis positive mother rats was compared to those of their mothers. The results are as follows: 1. 45 (= 14.6%) out of 308 sera from babies up to the age of 3 months reacted positively in the Sarcocystis antibody test. 2. 28 (= 62.2%) out of the 45 positive sera were from babies up to 2 weeks old, 13 (= 28.9%) were from babies older than 2 weeks but not more than 4 weeks old, and 2 (=4.4%) each were from babies whose ages ranged from 4 to 8, and 8 to 12 weeks respectively. 3. These babies acquired their Sarcocystis antibodies which decreased in the first 3 months of life from their mothers. 4. Litters born to serologic Sarcocystis positive mother rats also demonstrated Sarcocystis antibodies. The titres of these antibodies were at the same level as their mothers' at birth but reduced gradually so that most of these young rats were negative at the age of 3 months. 5. Suckling rats born to Sarcocystis negative mothers but positive fathers remained negative. 6. Serologic positive mother and father rats still demonstrated Sarcocystis antibodies in the sera at a time when their litters have become negative. 7. Sarcocystis antibodies could be passed onto the newborn from their positive mothers in both man and rats. 8. These antibodies were probably passed onto the newborn through the placenta but their passage through the colostrum and the mother's milk cannot be ruled out.

摘要

采用间接免疫荧光试验(IIFT)检测了3个月龄以内婴儿的血清中的肉孢子虫抗体。此外,还比较了血清学检测肉孢子虫呈阳性的母鼠所产仔鼠的肉孢子虫抗体水平与其母亲的抗体水平。结果如下:1. 在308份3个月龄以内婴儿的血清中,有45份(=14.6%)在肉孢子虫抗体检测中呈阳性反应。2. 在这45份阳性血清中,28份(=62.2%)来自2周龄以内的婴儿,13份(=28.9%)来自2周龄以上但不超过4周龄的婴儿,各有2份(=4.4%)分别来自4至8周龄和8至12周龄的婴儿。3. 这些婴儿从母亲那里获得了肉孢子虫抗体,这些抗体在出生后的头3个月里逐渐减少。4. 血清学检测肉孢子虫呈阳性的母鼠所产仔鼠也显示出肉孢子虫抗体。这些抗体的滴度在出生时与它们母亲的相同,但逐渐降低,因此大多数幼鼠在3个月龄时呈阴性。5. 父亲血清学呈阳性但母亲血清学呈阴性的哺乳幼鼠仍为阴性。6. 当它们的幼仔已呈阴性时,血清学呈阳性的父母鼠血清中仍显示有肉孢子虫抗体。7. 肉孢子虫抗体在人和大鼠中都可从阳性母亲传给新生儿。8. 这些抗体可能是通过胎盘传给新生儿的,但也不能排除通过初乳和母乳传递的可能性。

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