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多氯联苯导致小鼠的延迟着床和早期发育缺陷：2,2'-二氯联苯（作者译）

[Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl (author's transl)].

作者信息

Török P

出版信息

Arch Toxicol. 1978 Aug 9;40(4):249-54. doi: 10.1007/BF00310329.

DOI:10.1007/BF00310329
PMID:100080
Abstract

Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on the investigations during the early development it is concluded, that retardation of the fetus is caused by a delayed implantation. It is assumed, that increased resorption is due to kyematopathies detected during the periimplantation period.

摘要

在受孕后第1 - 3天（着床日 = 第0天）经口给予怀孕小鼠375毫克2,2'-二氯联苯/千克/天，在受孕第18天发现吸收增加，剂量从500毫克/千克/天起导致产前发育显著迟缓。基于早期发育期间的研究得出结论，胎儿发育迟缓是由着床延迟引起的。据推测，吸收增加是由于在着床前期检测到的血液病变。

相似文献

1
[Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl (author's transl)].多氯联苯导致小鼠的延迟着床和早期发育缺陷：2,2'-二氯联苯（作者译）
Arch Toxicol. 1978 Aug 9;40(4):249-54. doi: 10.1007/BF00310329.
2
Effect of 2,2'-dichlorobiphenyl (PCB) on the embryonic development of the NMRI mouse.2,2'-二氯联苯（多氯联苯）对NMRI小鼠胚胎发育的影响。
Environ Qual Saf Suppl. 1975;3:788-92.
3
Effects of long-term feeding of polychlorinated biphenyls (PCB, Clophen A 60) on the length of the oestrous cycle and on the frequency of implanted ova in the mouse.
Environ Res. 1973 Jun;6(2):176-9. doi: 10.1016/0013-9351(73)90031-5.
4
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Anat Anz. 1981;149(2):151-9.
5
Sexual functions of mice neonatally exposed to DDT or pcb.
Environ Physiol Biochem. 1975;5(1):54-7.
6
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Anat Anz. 1982;151(2):197-8.
7
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Jpn J Antibiot. 1975 Jun;28(3):366-71.
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Delayed pregnancy in NMRI mice treated with PCB:2,2'-dichlorobiphenyl.用多氯联苯：2,2'-二氯联苯处理的NMRI小鼠的妊娠延迟。
Bull Environ Contam Toxicol. 1976 Jul;16(1):33-6. doi: 10.1007/BF01753102.
9
[Effect of sex steroids on the fetus in the perinatal period].
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Arch Toxicol. 1977 Nov 21;38(4):261-74. doi: 10.1007/BF00352031.

本文引用的文献

1
Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls.关于油症（一种因摄入受多氯联苯商业品牌污染的米糠油而导致的中毒）的流行病学研究。
Environ Health Perspect. 1972 Apr;1:119-28. doi: 10.1289/ehp.7201119.
2
Endocrine studies on delayed implantation in lactating mice.哺乳期小鼠延迟着床的内分泌学研究。
J Endocrinol. 1955 Oct;13(1):1-6. doi: 10.1677/joe.0.0130001.
3
Polychlorinated biphenyls in the global ecosystem.全球生态系统中的多氯联苯。
Nature. 1968 Dec 14;220(5172):1098-102. doi: 10.1038/2201098a0.
4
Enhanced hepatic metabolism of testosterone, 4-androsterone-3,17-dione, and estradiol-17 in chickens pretreated with DDT or PCB.
Steroids. 1972 Jan;19(1):85-99. doi: 10.1016/0039-128x(72)90029-3.
5
Estrogen-induced surface coat and enzyme changes in the implanting mouse blastocyst.雌激素诱导植入期小鼠囊胚的表面被膜及酶变化。
J Embryol Exp Morphol. 1973 Jun;29(3):639-45.
6
Delayed pregnancy in NMRI mice treated with PCB:2,2'-dichlorobiphenyl.用多氯联苯：2,2'-二氯联苯处理的NMRI小鼠的妊娠延迟。
Bull Environ Contam Toxicol. 1976 Jul;16(1):33-6. doi: 10.1007/BF01753102.
7
Effect of 2,2'-dichlorobiphenyl (PCB) on the embryonic development of the NMRI mouse.2,2'-二氯联苯（多氯联苯）对NMRI小鼠胚胎发育的影响。
Environ Qual Saf Suppl. 1975;3:788-92.
8
Prolonged ingestion of commercial DDT and PCB; effects on progesterone levels and reproduction in the mature female rat.长期摄入商业用滴滴涕和多氯联苯；对成熟雌性大鼠孕酮水平和生殖的影响。
Arch Environ Contam Toxicol. 1975;3(4):479-90. doi: 10.1007/BF02220818.
9
Some aspects of the early development and implantation of the mammalian egg.哺乳动物卵子早期发育与着床的某些方面。
Experientia. 1976 May 15;32(5):542-8. doi: 10.1007/BF01990151.