Lorber A, Simon T, Leeb J, Peter A, Wilcox S
Arthritis Rheum. 1978 Sep-Oct;21(7):785-91. doi: 10.1002/art.1780210708.
Forty-four subjects with classic or definite rheumatoid arthritis who were on individualized chrysotherapy were observed for changes in serum protein electrophoresis, immunoglobulins, and circulating lymphocyte counts. By paired variate analysis, significant declines from pretreatment values were recorded for the following--electrophoretic protein fractions: gamma, alpha-1, alpha-2, (P less than 0.05); immunoglobulins: IgM--53% (P less than 0.001), IgG--37% (P less than 0.01), IgA--34% (P less than 0.001). Rheumatoid factor decreased in 29 of 39 subjects, 15 becoming seronegative (P less than 0.001); circulating lymphocytes decreased by 27% (P less than 0.001). The maximal suppressive effect on IgG and IgM was not achieved until the third and fourth years of therapy by sustained weekly administration of gold sodium thiomalate (one year cumulative dosage, mean 2106 mg, range 1065-2,885; greater than or equal to 4 year cumulative dosage, mean 8747 mg, range 5,385-15,160 mg). An immunosuppressive effect is suggested by these results.
对44名接受个体化金疗法的典型或确诊类风湿性关节炎患者，观察其血清蛋白电泳、免疫球蛋白和循环淋巴细胞计数的变化。通过配对变量分析，记录到以下指标较治疗前值有显著下降——电泳蛋白组分：γ、α-1、α-2（P<0.05）；免疫球蛋白：IgM——53%（P<0.001），IgG——37%（P<0.01），IgA——34%（P<0.001）。39名受试者中有29名类风湿因子下降，15名转为血清阴性（P<0.001）；循环淋巴细胞减少27%（P<0.001）。通过持续每周给予硫代苹果酸金钠（一年累积剂量，平均2106mg，范围1065 - 2885mg；≥4年累积剂量，平均8747mg，范围5385 - 15160mg），直到治疗的第三年和第四年才分别对IgG和IgM达到最大抑制作用。这些结果提示存在免疫抑制作用。
