对乙酰氨基酚（扑热息痛）对人体胃离子通量和电位差的影响。
Effect of paracetamol (acetaminophen) on gastric ionic fluxes and potential difference in man.
作者信息
Ivey K J, Settree P
出版信息
Gut. 1976 Nov;17(11):916-9. doi: 10.1136/gut.17.11.916.
Paracetamol has replaced aspirin as the analgesic of choice in many situations. The major reason is the damaging effect of aspirin on gastric mucosa. Alterations in gastric ionic fluxes and potential difference provide measures of aspirin-induced structural damage. We studied the effect of large doses of paracetamol (acetaminophen 2-0 g) on gastric ionic fluxes in man. In addition, the effect of 2-0 g paracetamol on gastric potential difference was compared with that of 600 mg aspirin. In contrast with salicylates, paracetamol caused no significant alteration in movement of H+ and Na+ ions over control periods. Aspirin causes a significant fall in transmucosal potential difference (PD) across gastric mucosa of 15 mv, while paracetamol cuased no significant change. Paracetamol in a dose four times that recommended does not alter gastric ionic fluxes or potential difference. These studies support choice of paracetamol as analgesic over aspirin where damage to gastric mucosa may be critical.
在许多情况下，对乙酰氨基酚已取代阿司匹林成为首选镇痛药。主要原因是阿司匹林对胃黏膜有损害作用。胃离子通量和电位差的改变可作为阿司匹林所致结构损伤的指标。我们研究了大剂量对乙酰氨基酚（2.0克醋氨酚）对人体胃离子通量的影响。此外，将2.0克对乙酰氨基酚对胃电位差的影响与600毫克阿司匹林的影响进行了比较。与水杨酸盐不同，在对照期内，对乙酰氨基酚不会引起H⁺和Na⁺离子运动的显著改变。阿司匹林可使胃黏膜跨黏膜电位差（PD）显著下降15毫伏，而对乙酰氨基酚则不会引起显著变化。剂量为推荐剂量四倍的对乙酰氨基酚不会改变胃离子通量或电位差。这些研究支持在胃黏膜损伤可能至关重要的情况下，选择对乙酰氨基酚而非阿司匹林作为镇痛药。
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