Strauss L, Santti R, Saarinen N, Streng T, Joshi S, Mäkelä S
Institute of Biomedicine and Medicity Research Laboratory, University of Turku, Finland.
Toxicol Lett. 1998 Dec 28;102-103:349-54. doi: 10.1016/s0378-4274(98)00332-4.
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated. In addition, the possible adverse effects of phytoestrogens have not been evaluated. It is plausible that phytoestrogens, as any exogenous hormonally active agent, might also cause adverse effects in the endocrine system, i.e. act as endocrine disrupters.
流行病学研究表明，富含植物雌激素（植物性雌激素）的饮食，特别是大豆和未精制谷物产品，可能与乳腺癌和前列腺癌的低风险相关。也有人提出，膳食中的植物雌激素可能在预防其他与雌激素相关的疾病中发挥作用，即心血管疾病、更年期症状和绝经后骨质疏松症。然而，没有直接证据表明植物雌激素对人类有益。所有信息均基于富含植物雌激素的饮食摄入情况，植物雌激素在人体内的因果关系和作用机制仍有待证明。此外，植物雌激素可能产生的不良影响尚未得到评估。植物雌激素作为任何外源性激素活性剂，有可能在内分泌系统中也会产生不良影响，即充当内分泌干扰物。
