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γ-氨基丁酸（GABA）对神经突生长的调节特性以及血清对培养的小鼠脊髓神经元的影响。

Neurite outgrowth-regulating properties of GABA and the effect of serum on mouse spinal cord neurons in culture.

作者信息

Bird M, Owen A

机构信息

Department of Anatomy, St Bartholomew's and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK.

出版信息

J Anat. 1998 Nov;193 ( Pt 4)(Pt 4):503-8. doi: 10.1046/j.1469-7580.1998.19340503.x.

DOI:10.1046/j.1469-7580.1998.19340503.x
PMID:10029183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1467875/
Abstract

Time-lapse photography was used to examine the effects of gamma-aminobutyric acid (GABA) on the outgrowth and motility of neurites in cultures from mouse spinal cord. GABA at concentrations of 100, 10 and 1 microM caused significant inhibition of neurite outgrowth and the motility of growth cones was significantly reduced by treatment with 100 and 10 microM GABA. This effect was mimicked by the GABA(B) receptor agonist baclofen, whereas the GABA(A) receptor agonist muscimol had no effect. The effect of GABA on outgrowth and motility seems to be dependent on the type of serum employed. The results reported here were obtained only when heat-inactivated serum was used and not when non heat-inactivated serum was added to the culture medium. They suggest that GABA has a role in the regulation of process outgrowth within the embryonic mouse spinal cord.

摘要

采用延时摄影技术研究γ-氨基丁酸（GABA）对小鼠脊髓培养物中神经突生长和运动的影响。浓度为100、10和1微摩尔的GABA可显著抑制神经突生长，用100和10微摩尔的GABA处理可显著降低生长锥的运动能力。GABA(B)受体激动剂巴氯芬可模拟此效应，而GABA(A)受体激动剂蝇蕈醇则无作用。GABA对生长和运动的影响似乎取决于所用血清的类型。此处报告的结果仅在使用热灭活血清时获得，而在培养基中添加未热灭活血清时则未获得。结果表明，GABA在胚胎小鼠脊髓内突起生长的调节中起作用。