Goldman M B, Goldman J N
J Immunol. 1976 Nov;117(5 Pt 1):1584-8.
The relationship between the H-2 complex and the complement system was studied by performing functional assays for whole complement and individual complement components on sera from congenic mice of B10 and C3H backgrounds. Levels of whole complement activity were seen to be influenced by S region genes, confirming the work of others. Levels of C3 through C9, however, were independent of the H-I genotypes suggesting that the differences in whole complement activities were due to variation in levels of C1, C4 or C2. Titrations of these three earliest acting classical complement components were performed on sera from mice of nine strains of the B10 background and four strains of the C3H background. It was shown that functional levels of C1, C4, and C2 were all under control of genes within or very closely linked to the S region.
通过对B10和C3H背景的同源基因小鼠血清进行全补体和单个补体成分的功能测定，研究了H-2复合体与补体系统之间的关系。全补体活性水平受S区基因影响，这证实了其他研究人员的工作。然而，C3至C9的水平与H-I基因型无关，这表明全补体活性的差异是由于C1、C4或C2水平的变化所致。对来自B10背景的9个品系和C3H背景的4个品系小鼠的血清进行了这三种最早起作用的经典补体成分的滴定。结果表明，C1、C4和C2的功能水平均受S区内或与S区紧密连锁的基因控制。
