Salas R A, Tovar D, Barreto A, de Miller E, Leitmeyer K, Rico-Hesse R
Instituto Nacional de Higiene Rafael Rangel, Ministerio de Sanidad y Asistencia Social, Caracas, Venezuela.
Acta Cient Venez. 1998;49 Suppl 1:33-7.
Due to the increasing severity of hemorrhagic dengue epidemics during the last years in Venezuela, a retrospective analysis was conducted to identify the behaviour of the dengue virus serotypes circulating in the country and the molecular evolution of dengue virus serotype 2. The data presented here indicates that dengue virus serotypes 1, 2 and 4 are endemic in Venezuela, they circulate simultaneously around the year in the biggest urban cities, however, one particular serotype is predominant during an epidemic period and replaces the virus serotype dominant during the previous epidemic period. The increased severity of dengue fever since 1989 in Venezuela might be associated to the introduction of the Asiatic genotype of virus which replaced the autochthonous Caribbean genotype. The Asiatic genotype is recognised as a more virulent virus.
由于近年来委内瑞拉出血性登革热疫情日益严重，开展了一项回顾性分析，以确定该国流行的登革热病毒血清型的行为以及登革热病毒2型的分子进化情况。此处呈现的数据表明，登革热病毒1型、2型和4型在委内瑞拉为地方病，它们全年同时在最大的城市中传播，然而，在疫情期间有一种特定血清型占主导地位，并取代了上一疫情期间占主导的病毒血清型。自1989年以来委内瑞拉登革热病情加重可能与引入取代了本土加勒比基因型的亚洲病毒基因型有关。亚洲基因型被认为是一种毒性更强的病毒。
