Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Av. Universidad 655, Santa María Ahuacatitlan, Cuernavaca, Morelos, México.
Arch Virol. 2010 Sep;155(9):1401-12. doi: 10.1007/s00705-010-0721-1. Epub 2010 Jun 15.
Both dengue fever and its more serious clinical manifestation, dengue hemorrhagic fever, represent major public health concerns in the Americas. To understand the patterns and dynamics of virus transmission in Mexico, a country characterized by a marked increase in dengue incidence in recent years, we undertook a molecular evolutionary analysis of the largest sample of Mexican strains of dengue virus compiled to date. Our E gene data set comprises sequences sampled over a period of 27 years and representing all of the Mexican states that are endemic for dengue. Our phylogenetic analysis reveals that, for each of the four dengue viruses (DENV-1 to DENV-4), there have been multiple introductions of viral lineages in Mexico, with viruses similar to those observed throughout the Americas, but there has been strikingly little co-circulation. Rather, dengue virus evolution in Mexico is typified by frequent lineage replacement, such that only a single viral lineage dominates in a specific serotype at a specific time point. Most lineage replacement events involve members of the same viral genotype, although a replacement event involving different genotypes was observed with DENV-2, and viral lineages that are new to Mexico are described for DENV-1, DENV-3 and DENV-4.
登革热及其更为严重的临床表现，即登革出血热，是美洲地区主要的公共卫生关注点。为了了解病毒在墨西哥的传播模式和动态，墨西哥近年来登革热发病率显著上升，我们对迄今汇编的最大的一批墨西哥登革热病毒株进行了分子进化分析。我们的 E 基因数据集包括在 27 年期间采样的序列，代表了所有存在登革热的墨西哥州。我们的系统发育分析表明，对于每一种四种登革热病毒（DENV-1 至 DENV-4），都有多种病毒谱系在墨西哥传入，这些病毒与在整个美洲观察到的病毒相似，但几乎没有共同循环。相反，墨西哥的登革热病毒进化的特点是频繁的谱系更替，以至于在特定的时间点，只有一种特定血清型的单一病毒谱系占主导地位。大多数谱系更替事件涉及同一病毒基因型的成员，尽管 DENV-2 观察到了涉及不同基因型的更替事件，而且还描述了对墨西哥来说是新的 DENV-1、DENV-3 和 DENV-4 病毒谱系。
