委内瑞拉 2 型登革热病毒的多样性和组成。
Diversity and composition of dengue virus type 2 in Venezuela.
机构信息
Research Programs Unit, Infection Biology & Department of Virology, Haartman Institute, University of Helsinki, Finland.
出版信息
Epidemiol Infect. 2013 Sep;141(9):1816-22. doi: 10.1017/S0950268812002324. Epub 2012 Oct 31.
Dengue is a mosquito-borne disease caused by four closely related dengue virus (genus Flavivirus)serotypes (DENV-1–4). The clinical outcomes vary from mild febrile illness to life-threatening haemorrhagic manifestations. DENVs are endemic in the tropics and subtropics globally and currently no specific treatment or vaccines are available. In Venezuela, the American-Asian genotype of DENV-2 is the most prevalent and has been associated with severe disease outcomes.We aimed to follow-up the molecular epidemiology of DENV-2 in Venezuela to investigate if the evolution of the virus has remained the same throughout time or if the same dynamics documented in Brazil (hyperendemic co-circulation) also occurred. The results show that whereas the epidemiology of DENV in several endemic areas is characterized by serotype replacements through time, in Venezuela the American-Asian genotype DENV-2 has evolved into several genetic lineages and has remained in hyperendemic co-circulation with the other serotypes.
登革热是一种由四种密切相关的登革病毒（黄病毒属）血清型（DENV-1-4）引起的蚊媒疾病。其临床表现从轻微发热到危及生命的出血表现各不相同。登革热病毒在全球热带和亚热带地区流行，目前尚无特效治疗或疫苗。在委内瑞拉，DENV-2 的美洲-亚洲基因型最为流行，与严重疾病结果有关。我们旨在对委内瑞拉的登革热病毒 2 型进行分子流行病学监测，以调查病毒的进化是否始终保持不变，或者是否也发生了在巴西记录的相同动态（高度流行的共同循环）。结果表明，尽管在一些流行地区，登革热病毒的流行病学特征是随着时间的推移而发生血清型更替，但在委内瑞拉，美洲-亚洲基因型 DENV-2 已进化成几个遗传谱系，并与其他血清型一起保持高度流行的共同循环。
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