Okuyama T, Korenaga D, Tamura S, Yao T, Maekawa S, Watanabe A, Ikeda T, Sugimachi K
Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan.
Surg Today. 1999;29(2):165-9. doi: 10.1007/BF02482243.
We report herein the case of a 46-year-old-man with small cell neuroendocrine carcinoma (NEC) concomitant with large villous adenoma of the rectum, who underwent abdominoperineal resection with regional lymphnode dissection. The resected specimen was histologically found to contain a small lesion of NEC confined to the submucosa in the large adenoma. A computed tomography scan done 4 months postoperatively revealed recurrences in the liver, lymph nodes, and bone. Therefore, two cycles of sequential intravenous combined chemotherapy with standard doses of cisplatin and 5-fluorouracil (5-FU) were administered, after which the size of each tumor decreased remarkably. Nevertheless, the patient died 8 months after the operation. As there was a fair response of this tumor to the combined chemotherapy of cisplatin and 5-FU, this regimen against NEC of the colon and rectum should be given consideration.
我们在此报告一例46岁男性患者，患有小细胞神经内分泌癌（NEC）并伴有直肠大绒毛状腺瘤，该患者接受了腹会阴联合切除术及区域淋巴结清扫术。经组织学检查，切除标本发现大腺瘤内有一个局限于黏膜下层的小NEC病灶。术后4个月进行的计算机断层扫描显示肝脏、淋巴结和骨骼出现复发。因此，给予两个周期的顺铂和5-氟尿嘧啶（5-FU）标准剂量序贯静脉联合化疗，之后每个肿瘤的大小显著减小。然而，患者术后8个月死亡。由于该肿瘤对顺铂和5-FU联合化疗有较好反应，因此应考虑将该方案用于治疗结肠和直肠的NEC。
