Pavelka K, Vojtisek O, Susta A, Kankova D, Bremova A, Kralova M
J Int Med Res. 1978;6(5):355-64. doi: 10.1177/030006057800600501.
Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis. In view of its exceptionally good tolerance it has become fashionable to prescribe increasingly large doses for severe cases or in those patients unable to tolerate other anti-rheumatic compounds. This study illustrates the sustained therapeutic benefit and almost complete lack of toxicity in fify-nine rheumatoid patients treated with up to 1,600 mg ibuprofen daily over six months. Significant improvement occurred in all clinical parameters and gastro-intestinal upset leading to discontinuance of therapy was reported in just two patients. There were no abnormalities in any of the biochemical tests performed.
布洛芬（异丁苯丙酸）是一种非甾体抗炎药，在类风湿性关节炎的症状治疗方面已得到充分认可。鉴于其耐受性特别好，对于重症病例或无法耐受其他抗风湿药物的患者，开具越来越大剂量的布洛芬已成为一种流行趋势。本研究表明，59名类风湿患者每日服用高达1600毫克布洛芬，持续治疗六个月，具有持续的治疗益处且几乎没有毒性。所有临床参数均有显著改善，仅有两名患者报告出现导致治疗中断的胃肠道不适。所进行的任何生化检查均未发现异常。
