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职业与霍奇金淋巴瘤

Occupation and Hodgkin's disease.

作者信息

Grufferman S, Duong T, Cole P

出版信息

J Natl Cancer Inst. 1976 Nov;57(5):1193-5. doi: 10.1093/jnci/57.5.1193.

Abstract

An incidence survey of Hodgkin's disease (HD) was conducted in the Boston Standard Metropolitan Statistical Area for 1959-73. Information on affected persons, 20 to 64 years old, was related to the 1960 and 1970 U.S. decennial censuses to evaluate the rates of HD in several occupational groups of special interest. No excess HD risk was found for two groups with high exposure to persons with the disease: Physicians had a relative risk (RR) of 1.2(0.4-2.6, 95% confidence interval) and nurses had an RR of 0.9 (0.4-1.8). Teachers, a group suggested to be at high risk due to exposure to "carriers" or contacts, had an RR of 1.1 (0.7-1.6). A high sex ratio, 1.9:1, at 35-64 years of age suggested that occupational exposures might increase disease risk. However, no difference in HD incidence was seen between employed and unemployed women in this age group. As in previous studies, woodworkers had an excess risk of HD [RR=1.6(0.9-2.6-a)], but the reason for this is obscure.

摘要

1959年至1973年期间,在波士顿标准大都市统计区开展了一项霍奇金淋巴瘤(HD)发病率调查。针对20至64岁的患者收集了相关信息,并与1960年和1970年美国十年一次的人口普查数据相关联,以评估几个特别感兴趣职业群体中的HD发病率。对于两个与该病患者有高接触的群体,未发现HD风险增加:医生的相对风险(RR)为1.2(0.4 - 2.6,95%置信区间),护士的RR为0.9(0.4 - 1.8)。教师群体因接触“携带者”或接触者而被认为风险较高,其RR为1.1(0.7 - 1.6)。35至64岁年龄段的性别比高达1.9:1,这表明职业暴露可能会增加患病风险。然而,在这个年龄段的就业女性和失业女性之间,HD发病率没有差异。与之前的研究一样,木工患HD的风险较高[RR = 1.6(0.9 - 2.6 - a)],但原因不明。

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