Scheer S, Douglas J M, Vittinghoff E, Bartholow B N, McKirnan D, Judson F N, MacQueen K M, Buchbinder S
AIDS Office, San Francisco Department of Public Health, California 94102-6033, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1;20(2):172-8. doi: 10.1097/00042560-199902010-00010.
We evaluated factors affecting the feasibility of including young high-risk HIV-negative gay and bisexual men in preventive HIV vaccine trials using data from the U.S. Centers for Disease Control and Prevention Collaborative HIV Seroincidence Study. Of 2189 men enrolled in this study, 17% were <25 years of age. HIV seroincidence was 4.2/100 person-years (95% confidence interval [CI], 2.6-7.0) in young men compared with 2.0/100 person-years (95% CI, 1.4-2.6) for older men. Compared with men 25 and older, young men were more likely to report several high-risk behaviors, to perceive themselves to be at risk for HIV infection, and to report that their risk behavior might be increased by participation in an HIV vaccine trial. The majority of both young men (69%) and older men (74%) expressed willingness in participate in HIV vaccine trials. Young men were less likely to answer questions about vaccine concepts correctly and were more likely to be lost to follow-up. Young gay and bisexual men are important candidates for future HIV vaccine trials, but they may need targeted approaches to recruitment, retention, education about trial concepts prior to enrollment, and behavioral interventions during the trial.
我们利用美国疾病控制与预防中心合作开展的HIV血清发病率研究数据，评估了影响将年轻的高危HIV阴性男同性恋者和双性恋者纳入预防性HIV疫苗试验可行性的因素。在这项研究纳入的2189名男性中，17%年龄小于25岁。年轻男性的HIV血清发病率为4.2/100人年（95%置信区间[CI]，2.6 - 7.0），而年长男性为2.0/100人年（95%CI，1.4 - 2.6）。与25岁及以上男性相比，年轻男性更有可能报告多种高危行为，认为自己有感染HIV的风险，并表示参与HIV疫苗试验可能会增加他们的风险行为。大多数年轻男性（69%）和年长男性（74%）都表示愿意参与HIV疫苗试验。年轻男性正确回答疫苗概念问题的可能性较小，失访的可能性更大。年轻的男同性恋者和双性恋者是未来HIV疫苗试验的重要候选人群，但可能需要有针对性的招募、留存、在入组前对试验概念进行教育以及在试验期间进行行为干预的方法。
