Kappel M, Poulsen T D, Galbo H, Pedersen B K
The Copenhagen Muscle Research Centre, Rigshospitalet, National University Hospital, Denmark.
Eur J Appl Physiol Occup Physiol. 1998 Dec;79(1):93-8. doi: 10.1007/s004210050479.
This study was designed to test the hypothesis that elevated plasma noradrenaline concentrations contribute to the exercise-induced modulation of the activity and percentage of the natural killer (NK) cells, and the leucocyte concentration. In a single blind, controlled, cross-over study, eight healthy men had noradrenaline infused for 1 h and achieved plasma noradrenaline concentrations comparable (20-fold increment) to those previously observed in cycle ergometer exercise (75% of maximal oxygen uptake for 1 h). The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-alpha stimulated NK cell activity, and the percentage of CD16+ cells. The natural lytic activity per CD16+ cell however, did not change. The concentration of neutrophils, lymphocytes and CD16+ cells increased during the infusion. The neutrophil concentration remained elevated 2 h after infusion, at which time the lymphocyte count was back to normal. These results are comparable with the effects in the exercise model, and it is suggested that the augmented plasma noradrenaline concentrations, seen during extreme exercise, may participate in the exercise-induced immune changes.
血浆去甲肾上腺素浓度升高会促使运动诱导自然杀伤（NK）细胞活性、百分比及白细胞浓度发生变化。在一项单盲、对照、交叉研究中，8名健康男性接受了1小时的去甲肾上腺素输注，使血浆去甲肾上腺素浓度达到与先前在自行车测力计运动中观察到的浓度相当（增加20倍）（1小时最大摄氧量的75%）。去甲肾上腺素输注增加了未受刺激的、白细胞介素-2和干扰素-α刺激的NK细胞活性以及CD16+细胞的百分比。然而，每个CD16+细胞的自然杀伤活性并未改变。输注期间中性粒细胞、淋巴细胞和CD16+细胞的浓度增加。输注后2小时中性粒细胞浓度仍保持升高，此时淋巴细胞计数恢复正常。这些结果与运动模型中的效应相当，提示在剧烈运动期间观察到的血浆去甲肾上腺素浓度升高可能参与了运动诱导的免疫变化。
