O'Connor G T, Gold D R
Department of Medicine, Boston Medical Center; Pulmonary Center, Boston University School of Medicine, Boston, MA 02118 USA.
Environ Health Perspect. 1999 Mar;107(3):243-7. doi: 10.1289/ehp.99107243.
A growing body of evidence has implicated allergens derived from cockroaches as an important environmental factor that may aggravate asthma in sensitized persons. We present the case of a 30-year-old man with asthma and a cockroach allergy. Allergy skin testing confirmed hypersensitivity to cockroach extract, and a home visit revealed visual evidence of infestation and the presence of Bla g 1 German cockroach allergen in vacuumed dust. As is typical of patients with a cockroach allergy and asthma, multiple factors in addition to cockroach allergen appeared to aggravate the patient's asthma. A multimodality therapeutic regimen, which included medications as well as cleaning of the home, integrated pest management, and professional application of chemical controls, resulted in substantial clinical improvement. The pathophysiology, epidemiology, and clinical features of cockroach-allergic asthma are reviewed, and an approach to diagnosis and management is suggested.
越来越多的证据表明，源自蟑螂的过敏原是一个重要的环境因素，可能会加重过敏者的哮喘症状。我们报告一例30岁患有哮喘和蟑螂过敏的男性病例。过敏皮肤试验证实对蟑螂提取物过敏，家访发现有蟑螂滋生的视觉证据，且在吸尘器收集的灰尘中存在德国小蠊过敏原Bla g 1。正如蟑螂过敏和哮喘患者的典型情况一样，除蟑螂过敏原外，多种因素似乎也加重了该患者的哮喘症状。一种多模式治疗方案，包括药物治疗以及家庭清洁、综合虫害管理和专业化学控制应用，使临床症状有了显著改善。本文回顾了蟑螂过敏性哮喘的病理生理学、流行病学和临床特征，并提出了诊断和管理方法。
