Porter J M, Bardana E J, Baur G M, Wesche D H, Andrasch R H, Rösch J
Surgery. 1976 Dec;80(6):756-64.
This study was performed to determine the frequency of occurrence of associated autoimmune disease in a group of patients presenting with Raynaud's symptoms. A consecutive group of 100 patients presenting with Raynaud's syndrome underwent detailed prospective clinical and immunologic evaluation. Magnificantion hand arteriography was performed in certain patients. Based on current diagnostic criteria, the following autoimmune diseases were diagnosed or were suspected strongly: Raynaud's syndrome with scleroderma or CRST--28 patients; Raynaud's syndrome with lupus erythematosus--ten patients; Raynaud's syndrome with miscellaneous autoimmune disease--43 patients: Raynaud's syndrome without diagnosable autoimmune disease--19 patients. Fourteen of the 19 patients in the latter group had isolated serologic abnormalities. Arteriography showed combined organic arterial obstruction and vasospasm of the palmar and digital arteries in all patients. Patients with severe Raynaud's symptoms had more extensive arterial obstruction than did patients with mild or moderate Raynaud's symptoms. These results suggest that all patients with Raynaud's syndrome should be regarded as at high risk for having an associated autoimmune disease.
本研究旨在确定一组出现雷诺氏症状的患者中相关自身免疫性疾病的发生频率。连续100例出现雷诺氏综合征的患者接受了详细的前瞻性临床和免疫学评估。部分患者进行了手部动脉造影。根据当前诊断标准，诊断或高度怀疑以下自身免疫性疾病：伴有硬皮病或CRST的雷诺氏综合征——28例；伴有红斑狼疮的雷诺氏综合征——10例；伴有其他自身免疫性疾病的雷诺氏综合征——43例；无可诊断自身免疫性疾病的雷诺氏综合征——19例。后一组19例患者中有14例有孤立的血清学异常。动脉造影显示所有患者均有掌部和指部动脉的器质性动脉阻塞和血管痉挛合并存在。重度雷诺氏症状患者的动脉阻塞比轻度或中度雷诺氏症状患者更广泛。这些结果表明，所有雷诺氏综合征患者都应被视为有相关自身免疫性疾病的高危人群。
