[正常眼压性青光眼患者的视网膜血流动力学。数字激光扫描荧光血管造影定量分析]

[Retinal hemodynamics in patients with normal pressure glaucoma. Quantification with digital laser scanning fluorescein angiography].

作者信息

Arend O, Remky A, Redbrake C, Arend S, Wenzel M, Harris A

机构信息

Universitäts-Augenklinik, RWTH Aachen.

出版信息

Ophthalmologe. 1999 Jan;96(1):24-9. doi: 10.1007/s003470050371.

DOI:10.1007/s003470050371

PMID:10067331

Abstract

UNLABELLED

Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG.

PATIENTS

Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 +/- 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis.

RESULTS

The AVP time in patients with NTG (2.78 +/- 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 +/- 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time.

CONCLUSION

Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.

摘要