Luty A J, Lell B, Schmidt-Ott R, Lehman L G, Luckner D, Greve B, Matousek P, Herbich K, Schmid D, Migot-Nabias F, Deloron P, Nussenzweig R S, Kremsner P G
Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany. adrian.
J Infect Dis. 1999 Apr;179(4):980-8. doi: 10.1086/314689.
The contribution of T cell-mediated responses was studied with regard to resistance to reinfection in groups of Gabonese children participating in a prospective study of severe and mild malaria due to infection with Plasmodium falciparum. In those admitted with mild malaria, but not in those with severe malaria, production of IFN-gamma by peripheral blood mononuclear cells (PBMC) in response to either liver-stage or merozoite antigen peptides was associated with significantly delayed first reinfections and with significantly lower rates of reinfection. Proliferative or tumor necrosis factor responses to the same peptides showed no such associations. Production of interferon-gamma by PBMC in response to sporozoite and merozoite antigen peptides was observed in a higher proportion of those presenting with mild malaria. Differences in the Th1/Th2 cytokine balance may be linked to the ability to control parasite multiplication in these young children, helping to explain the marked differences observed in both susceptibility to infection as well as in clinical presentation.
在参与一项关于恶性疟原虫感染所致严重和轻度疟疾前瞻性研究的加蓬儿童组中，研究了T细胞介导的反应对再次感染抵抗力的贡献。在那些患轻度疟疾的儿童中，而非患严重疟疾的儿童中，外周血单核细胞（PBMC）对肝期或裂殖子抗原肽产生的γ干扰素与首次再次感染显著延迟以及再次感染率显著降低有关。对相同肽的增殖或肿瘤坏死因子反应则无此类关联。在患轻度疟疾的儿童中，更高比例的儿童外周血单核细胞对子孢子和裂殖子抗原肽产生了γ干扰素。Th1/Th2细胞因子平衡的差异可能与这些幼儿控制寄生虫增殖的能力有关，这有助于解释在感染易感性和临床表现方面观察到的显著差异。
