Ghosh P, Taylor T K, Braund K G
Gerontology. 1977;23(2):99-109. doi: 10.1159/000212178.
The variation with age and spinal level of the glycosaminoglycan distribution in the greyhound (a non-chondrodystrophoid breed) intervertebral disc has been assessed by means of histochemical and chemical methods. The principal glycosaminoglycans of the greyhound disc are the chondroitin sulphates. With ageing, there is evidence of a decline in these components and the replacement by keratosulphate. The discs of this breed contain high proportions of sialic acid and hexosamines well into old age which are thought to be associated with non-collagenous proteins (glycoproteins). The maintenance of glycosaminoglycans and glycoprotein levels in the disc nucleus pulposus into old age is possibly associated with the relatively low incidence of disc disorders in the non-chondrodystrophoid breeds.
通过组织化学和化学方法评估了灵缇犬（一种非软骨发育不良品种）椎间盘内糖胺聚糖分布随年龄和脊柱节段的变化。灵缇犬椎间盘的主要糖胺聚糖是硫酸软骨素。随着年龄增长，有证据表明这些成分减少，并被硫酸角质素取代。该品种的椎间盘在老年时仍含有高比例的唾液酸和己糖胺，这些物质被认为与非胶原蛋白（糖蛋白）有关。椎间盘髓核中糖胺聚糖和糖蛋白水平在老年时的维持可能与非软骨发育不良品种椎间盘疾病发生率相对较低有关。
