Ghosh P, Taylor T K, Braund K G
Gerontology. 1977;23(2):87-98. doi: 10.1159/000212177.
The variation with age and spinal level of the glycosaminoglycan distribution in beagle (a chondrodystrophoid breed) intervertebral discs have been assessed by means of histochemical and chemical methods. Chondroitin sulphate is the major glycosaminoglycan of the immature beagle disc, but with ageing, this is partially replaced by keratosulphate. The level of glycosaminoglycans in the nucleus pulposus is markedly less than in the nonchondrodystrophoid breed and by 1 year of age, the beagle nucleus pulposus has become largely fibrocartilagious. This alteration in 'normal' disc developments is possibly associated with the elevated incidence of disc disorders in the chondrodystrophoid breeds.
通过组织化学和化学方法，评估了比格犬（一种软骨发育不良品种）椎间盘内糖胺聚糖分布随年龄和脊柱节段的变化。硫酸软骨素是未成熟比格犬椎间盘的主要糖胺聚糖，但随着年龄增长，它会部分被硫酸角质素取代。髓核中糖胺聚糖的水平明显低于非软骨发育不良品种，到1岁时，比格犬的髓核已基本变成纤维软骨。这种“正常”椎间盘发育的改变可能与软骨发育不良品种椎间盘疾病的高发病率有关。
