Hardt S E, Just A, Bekeredjian R, Kübler W, Kirchheim H R, Kuecherer H F
Department of Cardiology, Ruprecht-Karls Universität, 69115 Heidelberg, Germany.
Am J Physiol. 1999 Mar;276(3):H1078-85. doi: 10.1152/ajpheart.1999.276.3.H1078.
Intravascular ultrasound (IVUS) has emerged as an important diagnostic method for evaluating vessel diameter and vessel wall motion. To evaluate the validity of IVUS in assessing changes in the pressure-diameter relationship we compared measurements of abdominal aortic diameters derived from IVUS with those simultaneously obtained at the same site using implanted sonomicrometers in five chronically instrumented conscious dogs and in seven acutely instrumented anesthetized dogs. Five hundred eighty beats were analyzed to obtain peak systolic and end-diastolic diameters and to calculate aortic compliance at different blood pressure levels induced either by an aortic pneumatic cuff or by intravenous injections of nitroglycerin or norepinephrine. IVUS agreed closely with sonomicrometer measurements at different blood pressure levels. However, IVUS slightly but significantly underestimated aortic diameters by 0.6 +/- 0.7 mm for systolic diameters (P < 0.001) and by 0.7 +/- 0.6 mm for diastolic diameters (P < 0.001) compared with the sonomicrometer measurements. We conclude that IVUS is a feasible and reliable method to measure dynamic changes in aortic dimensions and has the potential to provide ready access to assess aortic compliance in humans.
血管内超声（IVUS）已成为评估血管直径和血管壁运动的重要诊断方法。为了评估IVUS在评估压力-直径关系变化方面的有效性，我们在五只长期植入仪器的清醒犬和七只急性植入仪器的麻醉犬中，将IVUS测量的腹主动脉直径与使用植入式超声微测计在同一部位同时获得的测量值进行了比较。分析了580次心跳，以获得收缩期峰值和舒张期末直径，并计算在通过主动脉气动袖带或静脉注射硝酸甘油或去甲肾上腺素诱导的不同血压水平下的主动脉顺应性。在不同血压水平下，IVUS与超声微测计测量值密切相符。然而，与超声微测计测量值相比，IVUS在收缩期直径上略微但显著低估了主动脉直径0.6±0.7毫米（P<0.001），在舒张期直径上低估了0.7±0.6毫米（P<0.001）。我们得出结论，IVUS是测量主动脉尺寸动态变化的一种可行且可靠的方法，并且有潜力为评估人类主动脉顺应性提供便捷途径。
