Utaş S, Ozbakir O, Turasan A, Utaş C
Department of Dermatology, University of Erciyes School of Medicine, Kayseri, Turkey.
J Am Acad Dermatol. 1999 Mar;40(3):433-5. doi: 10.1016/s0190-9622(99)70493-7.
A higher prevalence of Helicobacter pylori infection in rosacea patients than in healthy controls has been reported.
The aim of this study was to investigate the effect of H. pylori eradication therapy in patients with rosacea.
Twenty-five rosacea patients and 87 age- and sex-matched healthy controls were included in this study. We detected IgG and IgA antibodies against H. pylori in both groups. An upper gastrointestinal endoscopy and a rapid urease test were performed on the 13 patients with rosacea who accepted this procedure. Amoxicillin 500 mg 3 times daily, metronidazole 500 mg 3 times daily, and bismuth subcitrate 300 mg 4 times daily were administered to patients positive for H. pylori. The severity of rosacea was scored before and after treatment.
There was no statistical difference in seropositivity in either group. In H. pylori-positive rosacea patients there was a significant decrease in the severity of rosacea at the end of the treatment as compared with the initial scores.
Our findings suggest that H. pylori may be involved in rosacea and that eradication treatment may be beneficial.
有报道称酒渣鼻患者幽门螺杆菌感染率高于健康对照组。
本研究旨在探讨幽门螺杆菌根除治疗对酒渣鼻患者的影响。
本研究纳入了25名酒渣鼻患者和87名年龄及性别匹配的健康对照者。我们检测了两组中针对幽门螺杆菌的IgG和IgA抗体。对13名接受该检查的酒渣鼻患者进行了上消化道内镜检查和快速尿素酶试验。对幽门螺杆菌阳性的患者给予阿莫西林500毫克每日3次、甲硝唑500毫克每日3次、枸橼酸铋钾300毫克每日4次。在治疗前后对酒渣鼻的严重程度进行评分。
两组的血清阳性率无统计学差异。在幽门螺杆菌阳性的酒渣鼻患者中，与初始评分相比，治疗结束时酒渣鼻的严重程度显著降低。
我们的研究结果表明幽门螺杆菌可能与酒渣鼻有关，根除治疗可能有益。
