Levine J, Barak Y, Chengappa K N, Rapoport A, Rebey M, Barak V
Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Neuropsychobiology. 1999 Nov;40(4):171-6. doi: 10.1159/000026615.
There is increasing evidence for an association between the alteration of cytokine concentrations in blood and the pathophysiology of depressive disorders. Studies in humans have not investigated CSF cytokine concentrations and their relationship to depressive disorders. This study reports on the association of the CSF concentration of proinflammatory cytokines, IL-1beta, IL-6 and TNFalpha, and major depressive disorders. CSF samples were obtained from 13 hospitalized patients with acute unmedicated severe depression and were compared with 10 control subjects. Compared to the control group, the depressed patient group had higher CSF concentrations of IL-1beta, lower IL-6 and no change in TNFalpha. A positive correlation was found between serum IL-1beta and the severity of depression. These results indicate a unique profile for CSF proinflammatory cytokines in acute depression. These findings merit further investigation and if replicated may possibly offer immunological treatment options for depression.
越来越多的证据表明，血液中细胞因子浓度的改变与抑郁症的病理生理学之间存在关联。针对人类的研究尚未探究脑脊液细胞因子浓度及其与抑郁症的关系。本研究报告了促炎细胞因子白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNFα）在脑脊液中的浓度与重度抑郁症之间的关联。从13例急性未用药的重度抑郁症住院患者中获取脑脊液样本，并与10名对照受试者进行比较。与对照组相比，抑郁症患者组脑脊液中IL-1β浓度较高，IL-6浓度较低，TNFα浓度无变化。血清IL-1β与抑郁症严重程度之间存在正相关。这些结果表明急性抑郁症患者脑脊液促炎细胞因子具有独特特征。这些发现值得进一步研究，若能重复验证，可能会为抑郁症提供免疫治疗方案。
