Gharzouli K, Gharzouli A, Amira S, Khennouf S
Institute of Biology, Ferhat Abbas University, Setif, 19000, Algeria.
Pharmacol Res. 1999 Feb;39(2):151-6. doi: 10.1006/phrs.1998.0420.
The cytoprotective properties of various natural honey specimens and of a glucose-fructose-sucrose-maltose mixture (GFSM) against gastric ethanol-induced lesions have been evaluated in rats. GFSM mixture and honey (2.5 g kg-1) were given orally 30 min before administration of 100% ethanol (5 ml kg-1) for a further 15-min period. Animal pretreatment with GFSM or honey prevented the formation of gastric lesions. The number and severity of haemorrhagic lesions were reduced by 98%. Stomach acid content increased by 110-703% according to honey specimens. The similar protective effects of honey and GFSM mixture suggest that carbohydrates at high concentrations behave as mild irritants that can induce adaptive cytoprotection.
已在大鼠中评估了各种天然蜂蜜样本以及葡萄糖 - 果糖 - 蔗糖 - 麦芽糖混合物（GFSM）对胃乙醇诱导损伤的细胞保护特性。在给予100%乙醇（5 ml/kg-1）之前30分钟口服GFSM混合物和蜂蜜（2.5 g/kg-1），持续15分钟。用GFSM或蜂蜜对动物进行预处理可防止胃损伤的形成。出血性损伤的数量和严重程度降低了98%。根据蜂蜜样本，胃酸含量增加了110 - 703%。蜂蜜和GFSM混合物的类似保护作用表明，高浓度的碳水化合物表现为轻度刺激物，可诱导适应性细胞保护。
