Fazalda Annuar, Quraisiah Adam, Nur Azlina Mohd Fahami
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Evid Based Complement Alternat Med. 2018 Jul 15;2018:7515692. doi: 10.1155/2018/7515692. eCollection 2018.
Peptic ulcer is a basic term for ulcers on the lower oesophagus, stomach, or jejunum. The specific term for ulcer in the stomach is gastric ulcer. The extensive use of honey around the globe helps researchers to study the usefulness of honey. Many studies had already been conducted and proved the effectiveness of honey in treating gastric ulcer.
A systematic review of the literature was conducted to identify relevant studies on honey used as an alternative treatment of gastric ulcer cause by NSAIDs. A comprehensive search was conducted in Medline, SCOPUS, and Ebscohost. The main criteria used were articles published in English and using NSAIDs-induced gastric ulcer in rat's model and those reporting the effectiveness of honey.
Articles published between 2001 and 2014 were identified to be relevant in studies related to the inclusion criteria. The literature search found 30 potential and closely related articles in this review, but only 5 articles were taken which meet the criteria needed to be fulfilled.
All studies in this review reported the efficacy of honey for gastric ulcer based on its antioxidant and cytoprotective activities. Most of the studies conducted used different types of honey at various doses on rats. Future studies should be conducted to identify the appropriate dose for humans to achieve similar gastroprotective effects.
消化性溃疡是食管下段、胃或空肠溃疡的统称。胃溃疡是指胃内溃疡的特定术语。蜂蜜在全球的广泛应用有助于研究人员探究其治疗胃溃疡的效用。许多研究已经开展并证实了蜂蜜治疗胃溃疡的有效性。
进行文献系统综述，以确定有关蜂蜜作为非甾体抗炎药所致胃溃疡替代治疗方法的相关研究。在医学数据库（Medline）、科学网（SCOPUS）和EBSCOhost数据库中进行全面检索。主要纳入标准为发表的英文文章，使用大鼠非甾体抗炎药诱导胃溃疡模型，且报道了蜂蜜的有效性。
2001年至2014年发表的文章被确定与纳入标准相关的研究有关。文献检索在本次综述中发现30篇潜在且密切相关的文章，但仅选取了5篇符合所需标准的文章。
本综述中的所有研究均报道了蜂蜜基于其抗氧化和细胞保护活性对胃溃疡的疗效。大多数研究在大鼠身上使用了不同类型、不同剂量的蜂蜜。未来应开展研究以确定人类达到类似胃保护作用的合适剂量。
