Malpas T J, Darlow B A
Christchurch Women's Hospital, Christchurch.
N Z Med J. 1999 Jan 22;112(1080):12-3.
Neonatal abstinence syndrome is seen commonly in infants born to women on methadone maintenance. Many of these infants are breast-fed but few data are available on the distribution of methadone in breast milk, particularly for women receiving doses greater than 60 mg daily. We report two infants who appeared to develop neonatal abstinence syndrome, after abrupt discontinuation of breast-feeding by women receiving 70 mg and 130 mg of methadone. Women on methadone maintenance on high doses should be counselled to wean breast-feeding gradually.
新生儿戒断综合征常见于母亲接受美沙酮维持治疗期间出生的婴儿。这些婴儿中有许多是母乳喂养，但关于美沙酮在母乳中的分布数据很少，尤其是对于每日接受剂量超过60毫克的女性。我们报告了两名婴儿，他们似乎在接受70毫克和130毫克美沙酮的女性突然停止母乳喂养后患上了新生儿戒断综合征。应建议接受高剂量美沙酮维持治疗的女性逐渐停止母乳喂养。
