van den Heuvel E G, Muys T, van Dokkum W, Schaafsma G
TNO Nutrition and Food Research Institute, Department of Physiology, Zeist, Netherlands.
Am J Clin Nutr. 1999 Mar;69(3):544-8. doi: 10.1093/ajcn/69.3.544.
In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects.
The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents.
Twelve healthy, male adolescents aged 14-16 y received, for 9 d, 15 g oligofructose or sucrose (control treatment) daily over 3 main meals. The treatments were given according to a randomized, double-blind, crossover design, separated by a 19-d washout period. On the 8th day of each treatment period, 44Ca was given orally with a standard breakfast containing approximately 200 mg Ca. Within half an hour after administration of 44Ca, 48Ca was administered intravenously. Fractional calcium absorption was computed from the enrichment of 44Ca:43Ca and 48Ca:43Ca in 36-h urine samples, which was measured by inductively coupled plasma mass spectrometry.
An increase in true fractional calcium absorption (%) was found after consumption of oligofructose (mean difference +/- SE of difference: 10.8+/-5.6; P < 0.05, one sided). The results are discussed in relation to the methods used.
Fifteen grams of oligofructose per day stimulates fractional calcium absorption in male adolescents.
在大鼠中，不可消化的低聚糖可刺激钙的吸收。最近，在人类受试者中也发现了这种效应。
本研究的目的是调查每日摄入15 g低聚果糖是否能刺激男性青少年的钙吸收。
12名年龄在14 - 16岁的健康男性青少年，在9天时间里，于3顿主餐时每日摄入15 g低聚果糖或蔗糖（对照处理）。处理按照随机、双盲、交叉设计进行，中间间隔19天的洗脱期。在每个处理期的第8天，将44Ca与一份含约200 mg钙的标准早餐一起口服。在给予44Ca后半小时内，静脉注射48Ca。根据36小时尿液样本中44Ca:43Ca和48Ca:43Ca的富集情况计算钙的分数吸收，通过电感耦合等离子体质谱法进行测量。
摄入低聚果糖后，真实钙分数吸收（%）有所增加（平均差异±差异标准误：10.8±5.6；P < 0.05，单侧）。结合所使用的方法对结果进行了讨论。
每日15 g低聚果糖可刺激男性青少年的钙分数吸收。
