Li Li-Mei, Li Guo-You, Li Sheng-Hong, Weng Zhi-Ying, Xiao Wei-Lie, Han Quan-Bin, Ding Li-Sheng, Lou Li-Guang, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.
Chem Biodivers. 2006 Sep;3(9):1031-8. doi: 10.1002/cbdv.200690101.
Three new ent-kaurane diterpenoids, parvifoline Z (1), parvifoline AA (2), and parvifoline AB (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopy and mass spectrometry, and by comparison with known compounds. These three new diterpenoids included three types of ent-kauranoids, namely, C(20)-non-oxygenated-ent-kauranoid, 7,20-cyclo-ent-kauranoid and 6,7-seco-ent-kauranoid-7,20-olide. Compounds 1 and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines.
从小叶香茶菜的叶子中分离出了三种新的对映-贝壳杉烷二萜类化合物，即小叶香茶素Z（1）、小叶香茶素AA（2）和小叶香茶素AB（3），以及14种已知化合物。通过一维和二维核磁共振光谱、质谱以及与已知化合物进行比较，阐明了新化合物的结构。这三种新的二萜类化合物包括三种类型的对映-贝壳杉烷类化合物，即C(20)-无氧化对映-贝壳杉烷类化合物、7,20-环对映-贝壳杉烷类化合物和6,7-裂对映-贝壳杉烷类-7,20-内酯。化合物1和2对A549、HT-29和K562细胞系表现出显著的细胞毒性。
