从瓦努阿图采集的海洋海绵华丽扁海绵中提取的新型jaspa酰胺衍生物。
New jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu.
作者信息
Zampella A, Giannini C, Debitus C, Roussakis C, D'Auria M V
机构信息
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, via D. Montesano 49, 80131, Napoli, Italy.
出版信息
J Nat Prod. 1999 Feb;62(2):332-4. doi: 10.1021/np9803225.
Two new jaspamide derivatives (1 and 2) along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chemical structures were determined from 1D and 2D NMR studies and MS data. These two compounds inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with IC50 values in the microg/mL range.
从在瓦努阿图采集的海洋海绵灿烂扁海绵（Jaspis splendans）中分离出了两种新的jasplakinolide衍生物（1和2）以及jasplakinolide。它们的化学结构通过一维和二维核磁共振研究以及质谱数据得以确定。这两种化合物抑制NSCLC - N6人肿瘤细胞系的体外生长，其半数抑制浓度（IC50）值在微克/毫升范围内。
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