20 世纪 90 年代至 21 世纪 20 年代的天然聚丙酸盐：化学和生物多样性概述。

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China.

Mar Drugs. 2020 Nov 19;18(11):569. doi: 10.3390/md18110569.

Natural polypropionates (PPs) are a large subgroup of polyketides with diverse structural features and bioactivities. Most of the PPs are discovered from marine organisms including mollusks, fungi and actinomycetes, while some of them are also isolated from terrestrial resources. An increasing number of studies about PPs have been carried out in the past two decades and an updated review is needed. In this current review, we summarize the chemical structures and biological activities of 164 natural PPs reported in 67 research papers from 1999 to 2020. The isolation, structural features and bioactivities of these PPs are discussed in detail. The chemical diversity, bioactive diversity, biodiversity and the relationship between chemical classes and the bioactivities are also concluded.

天然聚丙酸酯（PPs）是聚酮类化合物的一个大群组，具有多样化的结构特征和生物活性。大多数 PPs 是从海洋生物中发现的，包括软体动物、真菌和放线菌，而其中一些也分离自陆地资源。在过去的二十年中，人们对 PPs 的研究越来越多，因此需要进行更新的综述。在本综述中，我们总结了 1999 年至 2020 年 67 篇研究论文中报道的 164 种天然 PPs 的化学结构和生物活性。详细讨论了这些 PPs 的分离、结构特征和生物活性。还总结了化学多样性、生物活性多样性、生物多样性以及化学类别与生物活性之间的关系。