• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane.

作者信息

Fanning A S, Anderson J M

机构信息

Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8019, USA.

出版信息

J Clin Invest. 1999 Mar;103(6):767-72. doi: 10.1172/JCI6509.

DOI:10.1172/JCI6509
PMID:10079096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC408156/
Abstract
摘要

相似文献

1
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane.PDZ结构域:质膜上蛋白质复合物组织中的基本构建模块。
J Clin Invest. 1999 Mar;103(6):767-72. doi: 10.1172/JCI6509.
2
Barriers built on claudins.基于紧密连接蛋白构建的屏障。
J Cell Sci. 2004 May 15;117(Pt 12):2435-47. doi: 10.1242/jcs.01235.
3
Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains.Scribble通过不同的分子结构域与两种极性蛋白Lgl2和Vangl2相互作用。
J Cell Biochem. 2006 Oct 1;99(2):647-64. doi: 10.1002/jcb.20992.
4
Phosphoinositide lipids and cell polarity: linking the plasma membrane to the cytocortex.磷脂酰肌醇脂质与细胞极性:将质膜与细胞质连接起来。
Essays Biochem. 2012;53:15-27. doi: 10.1042/bse0530015.
5
PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.上皮细胞中周边膜蛋白FRMPD2的PDZ结构域导向的基底外侧靶向作用
J Cell Sci. 2009 Sep 15;122(Pt 18):3374-84. doi: 10.1242/jcs.046854. Epub 2009 Aug 25.
6
Structure and function of PICK1.蛋白相互作用C激酶1(PICK1)的结构与功能
Neurosignals. 2006;15(4):190-201. doi: 10.1159/000098482. Epub 2007 Jan 11.
7
Transmembrane topology of mammalian planar cell polarity protein Vangl1.哺乳动物平面细胞极性蛋白 Vangl1 的跨膜拓扑结构。
Biochemistry. 2011 Mar 29;50(12):2274-82. doi: 10.1021/bi101767a. Epub 2011 Feb 25.
8
Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators.人类和灵长类肿瘤病毒利用PDZ结合作为一种进化上保守的靶向细胞极性调节剂的机制。
Oncogene. 2009 Jan 8;28(1):1-8. doi: 10.1038/onc.2008.365. Epub 2008 Sep 29.
9
Protein-binding domains of the tight junction protein, ZO-2, are highly conserved between avian and mammalian species.
Biochem Biophys Res Commun. 1998 Nov 27;252(3):617-22. doi: 10.1006/bbrc.1998.9710.
10
Protein modules as organizers of membrane structure.作为膜结构组织者的蛋白质模块。
Curr Opin Cell Biol. 1999 Aug;11(4):432-9. doi: 10.1016/S0955-0674(99)80062-3.

引用本文的文献

1
Identification and localization of adhesion G protein-coupled receptor expression in the murine kidney.小鼠肾脏中黏附G蛋白偶联受体表达的鉴定与定位
Am J Physiol Renal Physiol. 2025 Jul 1;329(1):F11-F19. doi: 10.1152/ajprenal.00134.2025. Epub 2025 May 15.
2
Hydroxy-selenomethionine helps cows to overcome heat stress by enhancing antioxidant capacity and alleviating blood-milk barrier damage.羟基硒代蛋氨酸通过增强抗氧化能力和减轻血乳屏障损伤来帮助奶牛克服热应激。
Anim Nutr. 2024 Nov 7;20:171-181. doi: 10.1016/j.aninu.2024.10.003. eCollection 2025 Mar.
3
Phosphoproteomic response to epidermal growth factor in native rat inner medullary collecting duct.天然大鼠内髓集合管对表皮生长因子的磷酸化蛋白质组学反应
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F29-F47. doi: 10.1152/ajprenal.00182.2024. Epub 2024 Nov 7.
4
Targeting PKCα alleviates iron overload in diabetes and hemochromatosis through the inhibition of ferroportin.靶向蛋白激酶Cα通过抑制铁转运蛋白来减轻糖尿病和血色素沉着症中的铁过载。
Blood. 2024 Sep 26;144(13):1433-1444. doi: 10.1182/blood.2024023829.
5
Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt -Glycosylation and Reduce Protein Stability.智力障碍和自闭症谱系障碍基因PTCHD1中的非同义突变破坏糖基化并降低蛋白质稳定性。
Cells. 2024 Jan 21;13(2):199. doi: 10.3390/cells13020199.
6
PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development.PDZ和LIM结构域编码基因:它们在癌症发展中的作用。
Cancers (Basel). 2023 Oct 19;15(20):5042. doi: 10.3390/cancers15205042.
7
The Architecture of the Presynaptic Release Site.突触前释放位点的结构。
Adv Neurobiol. 2023;33:1-21. doi: 10.1007/978-3-031-34229-5_1.
8
Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery.突破壁垒:针对动态紧密连接的新型靶向方法以改善药物递送。
Adv Drug Deliv Rev. 2023 Aug;199:114905. doi: 10.1016/j.addr.2023.114905. Epub 2023 Jun 3.
9
Novel organic selenium source hydroxy-selenomethionine counteracts the blood-milk barrier disruption and inflammatory response of mice under heat stress.新型有机硒源羟硒蛋氨酸可拮抗热应激小鼠血乳屏障破坏和炎症反应。
Front Immunol. 2022 Dec 1;13:1054128. doi: 10.3389/fimmu.2022.1054128. eCollection 2022.
10
Nuclear entry and egress of parvoviruses.细小病毒的核进入和核输出。
Mol Microbiol. 2022 Oct;118(4):295-308. doi: 10.1111/mmi.14974. Epub 2022 Aug 24.

本文引用的文献

1
alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration.α1-肌养蛋白基因缺失导致肌膜上缺乏神经元型一氧化氮合酶,但不会引发肌肉退化。
J Biol Chem. 1999 Jan 22;274(4):2193-200. doi: 10.1074/jbc.274.4.2193.
2
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.PDZ蛋白与Eph受体及其ephrin配体结合、聚集并在突触处共定位。
Neuron. 1998 Dec;21(6):1453-63. doi: 10.1016/s0896-6273(00)80663-7.
3
The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.NHERF和E3KARP在cAMP介导的NHE3抑制中的作用。
J Biol Chem. 1998 Nov 6;273(45):29972-8. doi: 10.1074/jbc.273.45.29972.
4
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.紧密连接蛋白ZO-1在跨膜蛋白闭合蛋白与肌动蛋白细胞骨架之间建立了一种联系。
J Biol Chem. 1998 Nov 6;273(45):29745-53. doi: 10.1074/jbc.273.45.29745.
5
The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.LIN-2/LIN-7/LIN-10复合物介导秀丽隐杆线虫表皮生长因子受体LET-23在外阴上皮细胞基底外侧膜的定位。
Cell. 1998 Sep 18;94(6):761-71. doi: 10.1016/s0092-8674(00)81735-3.
6
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.PDZ结构域介导的Eph相关受体酪氨酸激酶EphB3与Ras结合蛋白AF6之间的相互作用取决于该受体的激酶活性。
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9779-84. doi: 10.1073/pnas.95.17.9779.
7
TRP trapped in fly signaling web.瞬时受体电位通道被困于果蝇信号网络中。
Curr Opin Neurobiol. 1998 Jun;8(3):389-97. doi: 10.1016/s0959-4388(98)80066-4.
8
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins.通过PDZ结构域与靶蛋白之间的同聚和异聚相互作用来协调一系列信号蛋白。
J Cell Biol. 1998 Jul 27;142(2):545-55. doi: 10.1083/jcb.142.2.545.
9
An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton.一种顶端PDZ蛋白将囊性纤维化跨膜传导调节因子锚定到细胞骨架上。
J Biol Chem. 1998 Jul 31;273(31):19797-801. doi: 10.1074/jbc.273.31.19797.
10
CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.CRIPT,一种与PSD-95/SAP90的第三个PDZ结构域结合的新型突触后蛋白。
Neuron. 1998 Apr;20(4):693-707. doi: 10.1016/s0896-6273(00)81009-0.