神经肽肌肽的代谢转化会改变其生物活性。
Metabolic transformation of neuropeptide carnosine modifies its biological activity.
作者信息
Boldyrev A, Abe H
机构信息
International Biotechnological Center of M. V. Lomonosov Moscow State University, Russia.
出版信息
Cell Mol Neurobiol. 1999 Feb;19(1):163-75. doi: 10.1023/a:1006933028389.
Abstract
- The ability of carnosine and carnosine-related compounds (CRCs) to interact with several free oxygen radicals is analyzed. 2. Carnosine, the CRCs (imidazole, histidine, anserine), and ergothioneine were found to be equally efficient in singlet oxygen quenching. During generation of hydroxyl radicals from hydrogen peroxide in the Fenton reaction, carnosine was found to be more effective than the CRCs tested. 3. By measuring the chemiluminescence produced by carnosine and CRCs in rabbit leukocytes in the presence of luminol or lucigenin, we conclude that carnosine and other CRCs play a stimulating role in superoxide oxygen production while suppressing the myeloperoxidase system. 4. ADP-induced aggregation of human platelets is slightly stimulated by carnosine but is inhibited by acetylanserine. 5. The following rank order of efficiency of CRCs was demonstrated while measuring the oxidation of human serum lipoproteins: acetylcarnosine < acetylanserine < homocarnosine = ophidine < carnosine < anserine. 6. The results obtained demonstrate that metabolic transformation of carnosine into CRCs in tissues may play an important role in regulating the native antioxidant status of the organism.
摘要
- 分析了肌肽及肌肽相关化合物（CRCs）与几种游离氧自由基相互作用的能力。2. 发现肌肽、CRCs（咪唑、组氨酸、鹅肌肽）和麦角硫因在单线态氧猝灭方面同样有效。在芬顿反应中由过氧化氢生成羟基自由基的过程中，发现肌肽比所测试的CRCs更有效。3. 通过测量在鲁米诺或光泽精存在下肌肽和CRCs在兔白细胞中产生的化学发光，我们得出结论，肌肽和其他CRCs在超氧阴离子产生中起刺激作用，同时抑制髓过氧化物酶系统。4. 肌肽对ADP诱导的人血小板聚集有轻微刺激作用，但被乙酰鹅肌肽抑制。5. 在测量人血清脂蛋白氧化时，证明了CRCs的以下效率排序：乙酰肌肽＜乙酰鹅肌肽＜高肌肽 = 蛇肌肽＜肌肽＜鹅肌肽。6. 所获得的结果表明，组织中肌肽向CRCs的代谢转化可能在调节机体天然抗氧化状态中起重要作用。
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本文引用的文献
1
The buffering of muscle in rigor; protein, phosphate and carnosine.尸僵状态下肌肉的缓冲作用；蛋白质、磷酸盐和肌肽。
J Physiol. 1938 Apr 14;92(3):336-43. doi: 10.1113/jphysiol.1938.sp003605.
2
The significance of carnosine and anserine in striated skeletal muscle.肌肽和鹅肌肽在横纹肌中的意义。
Arch Biochem Biophys. 1960 Aug;89:303-8. doi: 10.1016/0003-9861(60)90059-x.
3
Carnosine: an endogenous neuroprotector in the ischemic brain.肌肽：缺血性脑内的内源性神经保护剂。
Cell Mol Neurobiol. 1999 Feb;19(1):45-56. doi: 10.1023/a:1006960407008.
4
Carnosine: its properties, functions and potential therapeutic applications.肌肽：其性质、功能及潜在的治疗应用。
Mol Aspects Med. 1992;13(5):379-444. doi: 10.1016/0098-2997(92)90006-l.
5
Quenching of singlet molecular oxygen by carnosine and related antioxidants. Monitoring 1270-nm phosphorescence in aqueous media.肌肽及相关抗氧化剂对单线态分子氧的猝灭。监测水介质中的1270纳米磷光。
Biochem Mol Biol Int. 1997 Apr;41(4):687-94. doi: 10.1080/15216549700201731.
6
Effects of carnosine and related compounds on generation of free oxygen species: a comparative study.肌肽及相关化合物对活性氧生成的影响：一项比较研究。
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7
The mechanism of interaction of carnosine with superoxide radicals in water solutions.肌肽在水溶液中与超氧自由基的相互作用机制。
Biochim Biophys Acta. 1993 Jul 11;1157(3):304-12. doi: 10.1016/0304-4165(93)90114-n.
8
[Lipoperoxidase activity of carnosine and carcinine].[肌肽和鹅肌肽的脂过氧化酶活性]
Dokl Akad Nauk. 1993 Nov;333(1):104-6.
9
Endogenous skeletal muscle antioxidants.内源性骨骼肌抗氧化剂。
Crit Rev Food Sci Nutr. 1994;34(4):403-26. doi: 10.1080/10408399409527669.
10
[Effect of carnosine and its derivatives on ADP-induced human platelet aggregation].肌肽及其衍生物对二磷酸腺苷诱导的人血小板聚集的影响
Vopr Med Khim. 1995 Jan-Feb;41(1):41-3.
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