肌肽：缺血性脑内的内源性神经保护剂。
Carnosine: an endogenous neuroprotector in the ischemic brain.
作者信息
Stvolinsky S L, Kukley M L, Dobrota D, Matejovicova M, Tkac I, Boldyrev A A
机构信息
Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Cell Mol Neurobiol. 1999 Feb;19(1):45-56. doi: 10.1023/a:1006960407008.
Abstract
- The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enzymatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions.
摘要
- 综述了天然亲水性神经肽肌肽对活性氧（ROS）病理生成的生物学效应。2. 我们描述了体外实验中观察到的直接抗氧化作用。3. 发现肌肽可间接影响代谢。这些效应反映在ROS周转调节和脂质过氧化（LPO）过程中。4. 在脑缺血期间，肌肽作为一种神经保护剂，有助于更好地恢复脑血流、使脑电图（EEG）正常化、减少乳酸积累，并对ROS具有酶促保护作用。5. 所呈现的数据表明，肌肽是神经元中基本代谢途径的特异性调节剂，在不利条件下支持脑稳态。
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