Smith M J, Walker J R, Ford-Hutchinson A W, Penington D G
Agents Actions. 1976 Nov;6(6):701-4. doi: 10.1007/BF02026091.
In exudates of implanted sponges in rats, made thrombocytopenic by the administration of anti-platelet serum, there are significant reductions in the platelet and leucocyte counts and of the content of prostaglandin-like activity. It is concluded that platelets migrate into the developing sponge exudates, are the source of the prostaglandins and interact with complement to cause leucocyte migration. In normal animals the administration of indomethacin and sodium salicylate cause similar effects to thrombocytopenia whereas the injection of human plasma fraction affects only the leucocyte migration. One of the sites of the anti-inflammatory action of conventional non-steroidal drugs may be concerned with the migration of platelets into inflammatory lesions.
在通过给予抗血小板血清使血小板减少的大鼠植入海绵的渗出物中，血小板和白细胞计数以及类前列腺素活性含量均显著降低。得出的结论是，血小板迁移到正在形成的海绵渗出物中，是前列腺素的来源，并与补体相互作用导致白细胞迁移。在正常动物中，给予吲哚美辛和水杨酸钠会产生与血小板减少症类似的效果，而注射人血浆成分仅影响白细胞迁移。传统非甾体药物抗炎作用的部位之一可能与血小板向炎症病变的迁移有关。
