Weinsier R L, Fuchs R J, Kay T D, Triebwasser J H, Lancaster M C
Am J Med. 1976 Dec;61(6):815-24. doi: 10.1016/0002-9343(76)90405-8.
Obesity is variably considered to be a major contributor to hypertension and hyperlipidemia, and its treatment is recommended in the management of coronary heart disease. Total body fat was measured by tritium dilution in a large male population and its relationship to age, blood pressure, serum lipids, uric acid and the diagnoses of coronary heart disease, hypertension and glucose intolerance was examined. In addition, three commonly used weight: height indices of obesity were correlated with each of these parameters. The correlation of body fat with blood pressure, serum cholesterol and triglycerides, although statistically significant, was of only small magnitude. Mean levels of body fat were not significantly different between patients with coronary disease and control subjects, whereas serum cholesterol and, to a lesser extent, systolic blood pressure were potent risk factors for the disease. It is concluded that obesity is only a minor determinant of blood pressure and lipid level, and that its contribution to coronary heart disease is small or nonexistent.
肥胖在不同程度上被认为是高血压和高脂血症的主要促成因素，并且在冠心病管理中建议对其进行治疗。通过氚稀释法在一大群男性人群中测量了全身脂肪，并研究了其与年龄、血压、血脂、尿酸以及冠心病、高血压和糖耐量异常诊断之间的关系。此外，还将三种常用的肥胖体重指数与上述每个参数进行了关联分析。体脂与血压、血清胆固醇和甘油三酯之间的相关性虽然具有统计学意义，但程度较小。冠心病患者和对照受试者之间的平均体脂水平没有显著差异，而血清胆固醇以及在较小程度上收缩压是该疾病的有力危险因素。结论是，肥胖只是血压和血脂水平的次要决定因素，其对冠心病的影响很小或不存在。
