锌对寄生曲霉中黄曲霉毒素生物合成相关腺嘌呤核苷酸库的影响。
Effect of zinc on adenine nucleotide pools in relation to aflatoxin biosynthesis in Aspergillus parasiticus.
作者信息
Gupta S K, Maggon K K, Venkitasubramanian T A
出版信息
Appl Environ Microbiol. 1976 Dec;32(6):753-6. doi: 10.1128/aem.32.6.753-756.1976.
The adenylic acid systems of Aspergillus parasiticus were studied in zinc-replete and zinc-deficient media. The adenosine 5'-triphosphate levels of the fungus were high during exponential phase and low during stationary phase in zinc-replete cultures. On the other hand, the levels of adenosine 5'-diphosphate and adenosine 5'-monophosphate were low during exponential phase of growth and high during stationary phase. The adenosine 5'-triphosphate levels during exponential phase may indicate higher primary metabolic activity of the fungus. On the other hand, high adenosine 5'-monophosphate levels during stationary phase may inhibit lipid formation and may enhance aflatoxin levels. The inorganic phosphorus content was low in a zinc-replete medium throughout the growth period, thereby favoring aflatoxin biosynthesis. The energy charge during the exponential phase was high but low during the stationary phase. In general the energy charge values were lower because of high adenosine 5'-monophosphate content.
在富含锌和缺锌的培养基中研究了寄生曲霉的腺苷酸系统。在富含锌的培养物中，真菌的腺苷5'-三磷酸水平在指数生长期较高，而在稳定期较低。另一方面，腺苷5'-二磷酸和腺苷5'-单磷酸的水平在生长指数期较低，而在稳定期较高。指数生长期的腺苷5'-三磷酸水平可能表明真菌的初级代谢活性较高。另一方面，稳定期较高的腺苷5'-单磷酸水平可能会抑制脂质形成，并可能提高黄曲霉毒素水平。在整个生长期间，富含锌的培养基中无机磷含量较低，从而有利于黄曲霉毒素的生物合成。指数生长期的能荷较高，但稳定期较低。一般来说，由于腺苷5'-单磷酸含量较高，能荷值较低。
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