McKenzie L S, Horsburgh B A, Ghosh P, Taylor T K
Ann Rheum Dis. 1976 Dec;35(6):487-97. doi: 10.1136/ard.35.6.487.
The anti-inflammatory drugs, sodium salicylate, indomethacin, hydrocortisone, ibuprofen, and flurbiprofen, were examined for their effects on sulphated glycosaminoglycan synthesis in aged human cartilage in vitro. Cartilage was obtained from femoral heads removed during surgery and drug effects were found to vary significantly from one head to another. Statistical analysis of the results showed that sodium salicylate exhibits concentration-dependent inhibition of glycosaminoglycan synthesis over the concentration range used. Indomethacin, hydrocortisone, and ibuprofen, at concentrations comparable to those attained in man, caused a statistically significant depression of sulphated glycosaminoglycan synthesis in cartilage from some femoral heads but not others, reflecting the variable response of human articular cartilage to anti-inflammatory drugs. Sodium salicylate and indomethacin at higher doses produced significant (Pless than 0-005) inhibition of sulphated glycosaminoglycan synthesis in all femoral heads studied. The results for flurbiprofen were less conclusive; this compound appears not to inhibit glycosaminoglycan synthesis over the concentration range used.
研究了抗炎药物水杨酸钠、吲哚美辛、氢化可的松、布洛芬和氟比洛芬对体外培养的老年人类软骨中硫酸化糖胺聚糖合成的影响。软骨取自手术中切除的股骨头,发现不同股骨头之间药物的作用差异显著。结果的统计分析表明,在所使用的浓度范围内,水杨酸钠对糖胺聚糖合成呈现浓度依赖性抑制。吲哚美辛、氢化可的松和布洛芬在与人达到的浓度相当的情况下,使一些股骨头软骨中的硫酸化糖胺聚糖合成出现统计学上显著的降低,但其他股骨头则不然,这反映了人类关节软骨对抗炎药物的反应存在差异。高剂量的水杨酸钠和吲哚美辛对所有研究的股骨头中的硫酸化糖胺聚糖合成均产生了显著(P小于0.005)抑制。氟比洛芬的结果不太明确;在所用浓度范围内,该化合物似乎不抑制糖胺聚糖合成。