Mitrovic D, Gruson M, Demignon J, Mercier P, Aprile F, De Seze S
Ann Rheum Dis. 1981 Feb;40(1):18-26. doi: 10.1136/ard.40.1.18.
The cell density and incorporation of 35SO4 and 3H-glycine into human articular cartilage from 8 osteoarthrotic and 7 normal (subcapital fracture) femoral heads were studied. It was found that osteoarthrotic cartilage incorporates on a per cell basis about twice as much 35SO4 and 2--5 times as much 3H-glycine as normal cartilage. There was no relationship between the intensity of incorporation and either the location of the cartilage (weight-bearing versus non weight-bearing areas) in normal cartilage or the degree of damage (normal-like, fibrillated, and ulcerated) in osteoarthrotic articular cartilage. In the latter tissue the increased synthetic capacity of the cells seems to be a diffuse rather than a localised process, for it was also found in cartilage from peripheral osteophytes. Histo-autoradiographic studies showed that the osteoarthrotic chondrocytes are metabolically hyperactive all over the femoral head, including wedge-shaped margins of the zone of exposed bone. These results support the hypothesis that much of the articular cartilage from osteoarthrotic femoral heads is of an immature chondroblastic type. It is suggested that de-novo synthesis of articular cartilage occurs during the process of regional remodelling of the femoral head, which would account for the observed hyperactivity.
研究了8个骨关节炎股骨头和7个正常（股骨头下骨折）股骨头的人关节软骨的细胞密度以及35SO4和3H-甘氨酸掺入情况。发现骨关节炎软骨按每个细胞计算掺入的35SO4约为正常软骨的两倍，3H-甘氨酸为正常软骨的2至5倍。在正常软骨中，掺入强度与软骨位置（负重区与非负重区）之间没有关系，在骨关节炎关节软骨中，掺入强度与损伤程度（正常样、纤维化和溃疡）之间也没有关系。在后者组织中，细胞合成能力的增加似乎是一个弥漫性而非局部性的过程，因为在外周骨赘的软骨中也发现了这种情况。组织放射自显影研究表明，骨关节炎软骨细胞在整个股骨头，包括暴露骨区域的楔形边缘，代谢都活跃。这些结果支持这样的假说，即来自骨关节炎股骨头的大部分关节软骨是未成熟的成软骨细胞类型。有人提出，关节软骨的从头合成发生在股骨头区域重塑过程中，这可以解释观察到的高活性。
