一种与人交叉反应独特型相关的免疫球蛋白重链可变区（VH）标志物。
An immunoglobulin heavy chain variable region (VH) marker associated with cross-reactive idiotypes in man.
作者信息
Feizi T, Lecomte J, Childs R
出版信息
Clin Exp Immunol. 1977 Nov;30(2):233-41.
Abstract
The VH specificities of two rabbit antisera raised against the H chains of two human IgM cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They were found to recognize a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal gamma globulin and strongly expressed on 8% of unselected myeloma and macroglobulinaemia proteins. There is evidence to suggest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.
摘要
借助于已有VH序列数据的蛋白质，研究了针对两种人IgM冷凝集素重链产生的两种兔抗血清的VH特异性。发现它们识别一种新的VH抗原（VHMar），它可能代表VHI的一个亚组。这种抗原存在于具有交叉反应独特型的抗Ii抗体上。它在正常丙种球蛋白中表达适中，在8%未经选择的骨髓瘤和巨球蛋白血症蛋白上强烈表达。有证据表明，抗Ii抗体中的一部分交叉反应独特型涉及这种VH抗原。
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J Exp Med. 1951 Feb;93(2):107-20. doi: 10.1084/jem.93.2.107.
2
The N-terminal sequence of a human gamma 1 chain of allotype Gm(a(-)f(+)).同种异型Gm(a(-)f(+))的人γ1链的N端序列。
FEBS Lett. 1969 Sep;5(1):20-22. doi: 10.1016/0014-5793(69)80282-6.
3
4
The sequence of the NH2-terminal cyanogen bromide fragment from the heavy chain of a gamma-G1 myeloma protein.γ-G1骨髓瘤蛋白重链的氨基末端溴化氰片段的序列。
J Biol Chem. 1970 Mar 25;245(6):1267-74.
5
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Proc Natl Acad Sci U S A. 1969 Nov;64(3):997-1003. doi: 10.1073/pnas.64.3.997.
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Proc Natl Acad Sci U S A. 1969 May;63(1):78-85. doi: 10.1073/pnas.63.1.78.
7
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Immunochemistry. 1971 Sep;8(9):801-11. doi: 10.1016/0019-2791(71)90447-2.
8
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