Husain S M, Mughal Z, Williams G, Ward K, Smith C S, Dutton J, Fraser W D
Department of Child Health, St Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London E9 6SR, UK.
Arch Dis Child. 1999 Apr;80(4):370-3. doi: 10.1136/adc.80.4.370.
Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.
尿吡啶啉和脱氧吡啶啉是成熟胶原分解过程中释放的吡啶鎓交联物，可能是骨吸收的有用标志物。在确定它们的作用之前，必须建立参考值。在本研究中，对250名4至10岁女孩和265名4至10岁男孩晨尿样本中的游离吡啶啉（f-Pyr）、游离脱氧吡啶啉（f-DPyr）和肌酐（Cr）进行了测量。总体而言，随着年龄增长，男女的f-Pyr:Cr和f-DPyr:Cr比值均下降，但同龄个体的值范围较宽。需要进一步研究来评估在影响骨代谢的情况下，尿吡啶鎓交联物排泄是否紊乱到足以使这些化合物的测量具有临床价值。
