Doull I, Freezer N, Holgate S
University of Medicine, Southampton General Hospital.
Arch Dis Child. 1996 Jun;74(6):497-501. doi: 10.1136/adc.74.6.497.
To determine the relationship between biochemical markers of bone metabolism and statural growth, and their suitability as surrogate markers of inhaled corticosteroid induced growth suppression.
Randomised, double blind, placebo controlled comparison of inhaled beclomethasone dipropionate 200 micrograms twice daily as dry powder for six months.
Southampton.
Serum osteocalcin, urinary deoxypyridinoline, and statural growth.
7 to 9 year old children with recurrent wheeze.
There were no significant differences in serum osteocalcin between the beclomethasone dipropionate and placebo group measured at baseline or after three and six months' treatment, while deoxy-pyridinoline was significantly higher in the placebo treated children after three months. Growth was significantly decreased in the beclomethasone dipropionate group over the course of the study. Growth over the six months, both in those receiving beclomethasone dipropionate and those receiving placebo, was significantly correlated with serum osteocalcin measured at three months and six months.
Although serum osteocalcin shows excellent correlation with growth, it is a poor marker for decreased growth associated with use of inhaled corticosteroids.
确定骨代谢生化标志物与身高增长之间的关系，以及它们作为吸入性糖皮质激素所致生长抑制替代标志物的适用性。
随机、双盲、安慰剂对照比较，每日两次吸入200微克二丙酸倍氯米松干粉，为期6个月。
南安普敦。
血清骨钙素、尿脱氧吡啶啉和身高增长。
7至9岁复发性喘息儿童。
在基线、治疗3个月和6个月时，二丙酸倍氯米松组与安慰剂组的血清骨钙素无显著差异，而在治疗3个月后，安慰剂治疗儿童的脱氧吡啶啉显著更高。在研究过程中，二丙酸倍氯米松组的生长显著下降。接受二丙酸倍氯米松治疗和接受安慰剂治疗的儿童在6个月内的生长与3个月和6个月时测量的血清骨钙素显著相关。
尽管血清骨钙素与生长具有良好的相关性，但它并非吸入性糖皮质激素使用所致生长下降的良好标志物。
