Desgrandchamps F, Griffith D P
Department of Urology, Saint-Louis Hospital, Paris, France.
Eur Urol. 1999 Apr;35(4):257-66. doi: 10.1159/000019858.
An artificial bladder should provide adequate urine storage, allow volitional complete evacuation of urine and preserve renal function. Moreover, its structure has to be biocompatible, resistant to urinary encrustation and tolerant to bacterial infection. Various solutions have been proposed over the years to achieve these multiple requirements. However, most of these solutions and their corresponding prototypes did not advance beyond the stage of a preliminary report of experimental data. This review will bring out the 'proof of principal' in alloplastic prosthetic bladder, including type of alloplast and design concept and the recent development in tissue engineering approaches.
人工膀胱应具备足够的尿液储存功能，允许自主完全排空尿液，并保护肾功能。此外，其结构必须具有生物相容性，能抵抗尿路结石形成且耐受细菌感染。多年来已提出各种解决方案以满足这些多重要求。然而，这些解决方案及其相应的原型大多未超越实验数据初步报告阶段。本综述将阐述异体人工膀胱的“原理证明”，包括异体材料的类型、设计理念以及组织工程方法的最新进展。
