异叶马兜铃根及茎中马兜铃酸的倍半萜酯类成分。

Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla.

作者信息

Wu T S, Chan Y Y, Leu Y L, Chen Z T

机构信息

Department of Chemistry, National Cheng Kung University, Tainan, Taiwan 701, Republic of China.

出版信息

J Nat Prod. 1999 Mar;62(3):415-8. doi: 10.1021/np980212y.

DOI:10.1021/np980212y

PMID:10096848

Abstract

Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.

摘要

从异叶马兜铃的根和茎中分离并鉴定出三种新的马兜铃酸倍半萜酯，马兜铃萜酯-II（2）、-III（3）和-IV（4），以及已知的马兜铃萜酯-I（1）。通过光谱方法阐明了它们的结构。通过圆二色性研究确定这些化合物在C-4'处的绝对构型为R。这些化合物对肝癌G2、2、2、15细胞显示出细胞毒性。