多克隆和单克隆来源的骨髓细胞中的细胞质免疫球蛋白
Cytoplasmic immunoglobulins in bone marrow cells of polyclonal and of monoclonal origin.
作者信息
Morell A, Skvaril F, Huser H J, Spengler G, Barandun S
出版信息
Acta Haematol. 1978;60(3):137-47. doi: 10.1159/000207710.
Cytoplasmic immunoglobulins in human bone marrow plasma cells and lymphoid cells were characterized by direct immunofluorescence with fluorochrome-labelled reagents specific for immunoglobulin heavy and light chains. The percentage distribution of cells containing IgA, IgG or IgM and kappa- or lambda-immunoglobulins was determined in bone marrow samples from 168 immunologically normal individuals, in 11 patients with polyclonal increase of bone marrow plasma cells and in 80 patients with benign or malignant monoclonal gammopathies. A clear differentiation between monoclonal and polyclonal cell populations could be obtained in all cases.
利用针对免疫球蛋白重链和轻链的荧光染料标记试剂，通过直接免疫荧光法对人骨髓浆细胞和淋巴细胞中的细胞质免疫球蛋白进行了表征。在168名免疫功能正常个体、11名骨髓浆细胞多克隆增多患者以及80名良性或恶性单克隆丙种球蛋白病患者的骨髓样本中，测定了含有IgA、IgG或IgM以及κ或λ免疫球蛋白的细胞的百分比分布。在所有病例中均可明确区分单克隆和多克隆细胞群体。
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