Prichep L S, Alper K R, Kowalik S C, Vaysblat L S, Merkin H A, Tom M, John E R, Rosenthal M S
Department of Psychiatry, New York University School of Medicine, NY 10016, USA.
Drug Alcohol Depend. 1999 Mar 1;54(1):35-43. doi: 10.1016/s0376-8716(98)00147-1.
This study investigates the existence of outcome related neurophysiological subtypes within a population of abstinent cocaine dependent adults. We have previously reported and replicated the existence of a distinctive quantitative EEG (QEEG) profile in such a population, and demonstrated the persistence of this pattern at one and six month follow-up evaluations. This profile is characterized by significant deficits of absolute and relative delta and theta power, and excess of relative alpha power, as compared with age expected normal values. Abnormalities were greater in anterior than posterior regions, and disturbances in interhemispheric relationships were also observed. In the current study, 35 adult males with DSM-III-R cocaine dependence, were evaluated while residents of a drug-free residential therapeutic community, 5-15 days after last use of crack cocaine. Using multivariate cluster analysis, two neurophysiological subtypes were identified from the baseline QEEGs; Cluster 1 characterized by significant deficits of delta and theta activity, significant excess of alpha activity and more normal amounts of beta activity (alpha CLUS) and Cluster 2 characterized by deficits of delta, more normal amounts of theta and anterior excess of alpha and beta activity beta CLUS). No significant relationships were found between QEEG subtype membership and length of exposure to cocaine, time since last use of cocaine or any demographic characteristics. Further, no significant relationships were found between the commonly reported comorbid clinical features of depression and anxiety and subtype membership. However, a significant relationship was found between QEEG subtype membership and length of stay in treatment, with members of the alpha CLUS retained in treatment significantly longer than members of the beta CLUS.
本研究调查了戒除可卡因的成年依赖者群体中与结果相关的神经生理亚型的存在情况。我们之前已经报道并重复证实在这样的群体中存在一种独特的定量脑电图（QEEG）特征，并在1个月和6个月的随访评估中证明了这种模式的持续性。与年龄预期的正常值相比，这种特征表现为绝对和相对δ波以及θ波功率显著降低，相对α波功率增加。前部区域的异常比后部区域更明显，并且还观察到半球间关系的紊乱。在当前研究中，对35名符合DSM-III-R可卡因依赖标准的成年男性进行了评估，他们是一个无毒品的住院治疗社区的居民，在最后一次使用快克可卡因后5 - 15天接受评估。使用多变量聚类分析，从基线QEEG中识别出两种神经生理亚型；第1组的特征是δ波和θ波活动显著降低，α波活动显著增加，β波活动量更正常（α波聚类），第2组的特征是δ波降低，θ波量更正常，前部α波和β波活动增加（β波聚类）。未发现QEEG亚型归属与可卡因接触时长、最后一次使用可卡因后的时间或任何人口统计学特征之间存在显著关系。此外，在常见报道的抑郁和焦虑共病临床特征与亚型归属之间未发现显著关系。然而，发现QEEG亚型归属与治疗停留时长之间存在显著关系，α波聚类的成员在治疗中的停留时间显著长于β波聚类的成员。
