Prichep L S, Alper K R, Kowalik S, Merkin H, Tom M, John E R, Rosenthal M S
Department of Psychiatry, New York University Medical Center, New York 10016, USA.
Biol Psychiatry. 1996 Nov 15;40(10):986-93. doi: 10.1016/0006-3223(95)00575-7.
This study replicates preliminary findings reporting a quantitative electroencephalographic (QEEG) profile of crack cocaine dependence in abstinence. All subjects (n = 52) met criteria for DMS-III-R cocaine dependence (in the form of crack), and were residing in a drug-free therapeutic community. Baseline QEEG evaluations were conducted at intake (5-10 days after last use of crack, and at follow-up (1 month after last reported use). Previous findings of significant excess of relative alpha power and deficit of absolute and relative delta and theta power were replicated in this expanded group. Abnormalities were greater in anterior than posterior regions, and disturbances in interhemispheric relationships were also observed. Further, QEEG showed little change in the interval between the first and second evaluations. This QEEG profile may reflect persistent alterations in neurotransmission as a possible consequence of chronic cocaine exposure.
本研究重复了初步研究结果，该结果报告了戒除可卡因成瘾者的定量脑电图（QEEG）特征。所有受试者（n = 52）均符合《精神疾病诊断与统计手册第三版修订本》（DMS-III-R）中可卡因成瘾（以快克可卡因形式）的标准，且居住在无毒品的治疗社区。在入组时（最后一次使用快克可卡因后5 - 10天）和随访时（最后一次报告使用后1个月）进行了基线QEEG评估。在这个扩大的群体中重复了先前的研究结果，即相对α波功率显著过剩，绝对和相对δ波以及θ波功率不足。前部区域的异常比后部区域更明显，并且还观察到半球间关系的紊乱。此外，QEEG显示在第一次和第二次评估之间的间隔内变化很小。这种QEEG特征可能反映了作为慢性可卡因暴露可能后果的神经传递的持续改变。
